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用小剂量亚胺培南/西司他丁治疗18例肺部感染患者,通过细菌培养、检测血药浓度动态变化及支气管肺泡灌洗液(BAL)的药物浓度测定,以探讨小剂量亚胺培南/西司他丁治疗肺部感染的适用价值。结果显示:致病菌阴转率为89%,治疗的有效率为89%;静滴后1.5hBAL中药物浓度为1.312±0.161μg/ml;血药峰浓度为37.32±9.57μg/ml,用药8h后降为0.91±0.11μg/ml,半衰期约为1h。
Eighteen patients with pulmonary infection were treated with low dose imipenem / cilastatin, and the dynamic changes of plasma concentration and the concentration of bronchoalveolar lavage fluid (BAL) were detected by bacterial culture to explore the effect of low dose imine Pei Nan / cilastatin in the treatment of pulmonary infection of the value. The results showed that the negative conversion rate of pathogenic bacteria was 89% and the effective rate of treatment was 89%. After 1.5 hours of intravenous infusion, the concentration of drug was 1.312 ± 0.161μg / ml and the peak plasma concentration was 37.32 ± 9.57μg / ml, dropping to 0.91 ± 0.11μg / ml after 8h, the half-life was about 1h.