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Barrett食管(BE)是食管腺癌(EA)的癌前病变。准确诊断BE,是降低EA风险的主要手段。近10余年来,EA的发病率在西方国家明显增加,在国内也有上升趋势,并引起广泛重视。由于有时内窥镜下识别食管胃交界解剖部位存在困难,显微镜下又不易区别BE肠化和胃贲门肠化,使一些BE不能准确诊断。本文对BE及EA近年来蛋白及分子标记物的研究进行综述,希望对BE及EA的诊断提供有益的思路。
Barrett’s esophagus (BE) is a precancerous lesion of esophageal adenocarcinoma (EA). Accurate diagnosis of BE is the main means of reducing the risk of EA. In the past 10 years, the incidence of EA has obviously increased in western countries, and it has also been on the rise in China, which has drawn wide attention. Because sometimes under endoscopy to identify anatomical parts of esophageal and stomach junction difficult, under the microscope is not easy to distinguish between BE intestinal and gastric cardia intestinal metaplasia, so that some BE can not be accurately diagnosed. This review summarizes the recent studies on the proteins and molecular markers of BE and EA, and hopes to provide useful ideas for the diagnosis of BE and EA.