论文部分内容阅读
目的研究间皮素(mesothelin)在上皮性卵巢癌血清及尿液中的表达水平,与血清CA125联合检测上皮性卵巢癌的临床应用价值。方法 2009年4月在郑州大学第一附属医院,采用ELISA法检测41例上皮性卵巢癌、32例卵巢良性肿瘤、30例正常人群血清及尿液间皮素水平和血清CA125水平。结果卵巢癌患者血清及尿液中间皮素水平明显高于卵巢良性肿瘤组和正常对照组,差异有统计学意义(P<0.01),血清及尿液间皮素水平在卵巢良性肿瘤组与正常对照组间差异均无统计学意义(P>0.05)。血清间皮素检测上皮性卵巢癌敏感度、特异度分别为58.5%、83.9%,联合血清CA125检测其敏感度、特异度分别为85.4%、85.5%;尿液间皮素检测上皮性卵巢癌的敏感度、特异度分别68.3%、93.5%,联合血清CA125检测其敏感度、特异度分别为92.7%、96.8%,联合血清间皮素、尿液间皮素和血清CA125检测其灵敏度和特异度为95.1%、96.8%。结论血清及尿液间皮素联合CA125检测将有助于卵巢癌的早期检测。
Objective To study the expression of mesothelin in the serum and urine of epithelial ovarian cancer and to evaluate its clinical value in combination with serum CA125 in the detection of epithelial ovarian cancer. Methods The serum and urine mesothelin levels and serum CA125 levels in 41 cases of epithelial ovarian cancer, 32 cases of benign ovarian tumor and 30 normal controls were detected by ELISA in the First Affiliated Hospital of Zhengzhou University in April, 2009. Results Serum and urine mesothelin levels in patients with ovarian cancer were significantly higher than those in benign ovarian tumors and normal controls (P <0.01). Serum and urine mesothelin levels were significantly different between benign ovarian tumors and normal controls There was no significant difference between control groups (P> 0.05). The sensitivity and specificity of serum mesothelin in the detection of epithelial ovarian cancer were 58.5% and 83.9%, respectively. The sensitivity and specificity of combined serum CA125 were 85.4% and 85.5% respectively. Urinary mesothelin was used to detect epithelial ovarian cancer The sensitivity and specificity were 68.3% and 93.5% respectively. The sensitivity and specificity of combined serum CA125 were 92.7% and 96.8% respectively. The sensitivity and specificity of combined detection of serum mesothelin, urinary mesothelin and serum CA125 Degree was 95.1%, 96.8%. Conclusion serum and urine mesothelin combined with CA125 test will help early detection of ovarian cancer.