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目的:检测成纤维细胞激活蛋白α(FAP-α)在胃癌组织中的表达情况,分析其表达的临床意义。方法:收集自2008年6月1日至2010年12月30日在广东医学院附属医院行手术切除,并且全部经过病理诊断证实为胃腺癌的患者98例,伴癌旁组织者20例。同时追踪随访患者生存情况截止至2015年12月30日。收集经胃镜取材诊断为胃炎的患者10例。应用免疫组织化学方法检测FAP-α在胃癌组织、癌旁组织及胃炎组织中的表达。分析FAP-α的表达与胃癌临床病理特征的关系及患者预后的相关性。结果:FAP-α在癌旁组织及胃炎组织中不表达,在胃癌组织中主要分布于胃癌实质腺细胞,在胃癌间质中呈少量分布。FAP-α在胃癌组织中的表达与性别、年龄、肿瘤分级、肿瘤大小、浸润深度及淋巴结转移等不具有相关性(P>0.05),与患者术后生存期呈负相关,即FAP-α表达越多,患者术后生存期越短(P=0.035)。结论:FAP-α主要表达于胃癌实质腺细胞。FAP-α的表达与患者性别、年龄、肿瘤分级、肿瘤大小、浸润深度及淋巴结转移等因素之间不具有相关性,与患者术后生存期呈负相关,可用于作为评估患者预后的指标。
Objective: To detect the expression of fibroblast activating protein α (FAP-α) in gastric cancer and to analyze its clinical significance. Methods: From June 1, 2008 to December 30, 2010, 98 patients with gastric adenocarcinoma who underwent surgical resection in Guangdong Medical College Affiliated Hospital and 20 patients with adjacent tissues were collected. At the same time follow-up of patients with survival as of December 30, 2015. Ten patients with gastritis diagnosed as gastritis were collected. Immunohistochemistry was used to detect the expression of FAP-α in gastric cancer tissues, adjacent tissues and gastritis tissues. To analyze the relationship between the expression of FAP-α and the clinicopathological characteristics of gastric cancer and the prognosis of patients. Results: FAP-α was not expressed in adjacent tissues and gastritis tissues. In gastric cancer tissues, FAP-α mainly distributed in the glandular gland cells of gastric carcinoma, with a small amount of distribution in the gastric cancer stroma. The expression of FAP-α in gastric cancer tissues was not correlated with sex, age, tumor grade, tumor size, depth of invasion and lymph node metastasis (P> 0.05), but negatively correlated with the survival time of patients with FAP-α The more patients expressed, the shorter the postoperative survival (P = 0.035). Conclusion: FAP-α is mainly expressed in the glandular cells of gastric cancer. The expression of FAP-α was not related to the gender, age, tumor grade, tumor size, depth of invasion and lymph node metastasis, but negatively correlated with the postoperative survival of patients. It could be used as an index to evaluate the prognosis of patients.