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目的通过冠脉造影患者术前术后肾功能相关指标对比,探讨造影剂对肾功能的亚临床影响。方法选择择期进行冠状动脉造影手术的患者,分别测定其术前、术后48 h的血肌酐(Cr)、血β2-微球蛋白、尿β2-微球蛋白、24 h尿钾2、4 h尿钠、24 h尿蛋白定量以及24 h尿微量白蛋白的值,进行比较分析。结果在血Cr无明显上升情况下,尿β2-微球蛋白2、4 h尿钾、尿钠前后差异明显,其中尿β2-微球蛋白2、4 h尿钾的差异具有统计学意义(P<0.05),其余指标如血β2-微球蛋白,24 h尿钠变化趋势明确,但差别尚未有统计学意义。结论造影剂对亚临床肾功能存在一定影响,尤其对肾小管功能影响比较明显。
Objective To compare the renal related indexes before and after coronary angiography in patients undergoing coronary angiography to investigate the subclinical effects of contrast medium on renal function. Methods Patients undergoing elective coronary angiography were enrolled in this study. Serum creatinine (Cr), serum β2-microglobulin, urinary β2-microglobulin, urinary potassium 24 h Urine sodium, 24 h urinary protein and 24 h urinary albumin were compared and analyzed. Results Urinary β2-microglobulin showed a significant difference in urinary potassium and urinary sodium concentrations before and after 2,4-hour urinary excretion of urinary β2-microglobulin, while urine urinary β2-microglobulin at 2,4 and urinary potassium levels had statistical significance (P <0.05), other indicators such as blood β2-microglobulin, 24 h urine sodium clear trend, but the difference has not yet statistically significant. Conclusions Contrast medium has certain influence on subclinical renal function, especially on renal tubular function.