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目的了解正常中孕期妇女血清维生素B12水平。方法对1 680名正常中孕期妇女采用电化学发光免疫分析法检测血清维生素B12水平,并按不同孕周和年龄进行比较分析。结果正常中孕期妇女血清维生素B12水平为276.70(127.75~581.77)pmol/L,采用多元线性回归分析结果为YB12=5.583-0.044X孕周+0.071X年龄,F=34.34,P<0.01,R2=0.04。中孕期妇女血清维生素B12水平,随着孕周增加呈现逐渐下降趋势(P<0.01);随着孕妇年龄增长呈现逐渐升高趋势(P<0.01)。结论正常中孕期妇女维生素B12水平在孕周和年龄上存在差异,应根据孕妇孕周、年龄采用不同的参考区间来判断其是否存在维生素B12缺乏。
Objective To understand the level of serum vitamin B12 in normal pregnant women. Methods A total of 1 680 normal pregnant women were tested for the level of serum vitamin B12 by electrochemiluminescence immunoassay and compared according to different gestational age and age. Results The level of serum vitamin B12 in normal pregnant women was 276.70 (127.75 ~ 581.77) pmol / L. The multiple linear regression analysis showed YB12 = 5.583-0.044X + 0.071X, F = 34.34, P < 0.04. The level of serum vitamin B12 in the second trimester decreased gradually with the increase of gestational age (P <0.01), and gradually increased with the increase of pregnant women (P <0.01). Conclusion There are differences in gestational age and age between the levels of vitamin B12 in normal middle-pregnant women. Different reference intervals should be used according to gestational ages and ages of pregnant women to determine whether there is vitamin B12 deficiency.