伤寒发病机理的研究进展

• 作 者: 何树初
• 机 构: 中山医学院第三附属医院传染病科,
• 出 处: 国外医学(内科学分册)
• 发表日期: 1980年01期
• 关键词: 伤寒 发病机理 杆菌 小肠粘膜 雾化吸入 内毒素 胃肠道 吞噬作用 伤寒病 生化机理

近年来,对于伤寒发病机理的研究已取得不少的进展,现综述如下。病原体的作用目前认为,伤寒杆菌的入侵门户是胃肠道,可能是小肠上段。对“志愿者”的研究表明,口服的伤寒杆菌可以在24小时内从粪便中被分离出,但通常在数天内便从粪便中消失。咽喉部曾一度被认为是开始入侵的部位,但这种可能性已被排除,因为“志愿者”雾化吸入伤寒杆菌之后并不发病。伤寒杆菌入侵小肠粘膜上皮的生化机理尚未明了,但其过程可能和细胞的吞噬作用相似。当伤寒杆菌靠近粘膜上皮时,上皮的纤

In recent years, the research on the pathogenesis of typhoid fever has made a lot of progress, are summarized below. The role of pathogens Currently that the typhoid typhoid invasion portal is the gastrointestinal tract, may be the upper small intestine. Studies of “volunteers” have shown that oral Salmonella typhi can be isolated from the stool within 24 hours, but usually disappear from the stool within days. The throat was once considered to be the site of invasion, but this possibility has been ruled out because “volunteers” are not morbid after inhaling Salmonella typhi. The biochemical mechanism of Salmonella typhi invasion of small intestinal mucosal epithelium is unclear, but the process may be similar to the phagocytosis of cells. When typhoid bacteria close to the mucosal epithelium, epithelial fibers