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本研究用多管微电极细胞外记录和离子微电泳方法，以Wistar大鼠为实验对象，观察了P物质（SP）对脊髓背角神经元自发放电和慢性伤害性痛放电的影响以及与5-羟色胺（5－HT）和生长抑素（SOM）的关系。结果表明：（1）电泳SP可使脊髓背角神经元单位放电增多。（2）电泳SP又可抑制福尔马林（Formalin）引起的神经元慢性伤害性痛放电。（3）电泳5－HT和SOM可抑制SP及慢痛诱发的脊髓背角神经元放电。上述结果提示：在痛觉调制过程中，脊髓内SP起着传递痛觉信息和镇痛的双重作用，5－HT和SOM可通过抑制SP的效应，参与痛觉调制。
In this study, with multi-tube microelectrode extracellular recording and ion micro-electrophoresis method to Wistar rats as experimental subjects to observe the substance P (SP) on spontaneous discharge of spinal dorsal horn neurons and chronic nociceptive discharge and 5 - serotonin (5-HT) and somatostatin (SOM) relationship. The results showed that: (1) Electrophoresis SP can increase the unit discharge of spinal dorsal horn neurons. (2) Electrophoretic SP can inhibit formalin-induced neuronal chronic nociceptive discharge. (3) Electrophoresis 5-HT and SOM can inhibit SP and slow pain-induced dorsal horn neuron discharge. The above results suggest that SP plays a dual role in transmitting pain information and analgesia during pain modulation. 5-HT and SOM may participate in the modulation of pain by inhibiting the effects of SP.