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自从1976年发现产生青霉素酶的淋球菌以来,青霉素已经不是治疗淋病的首选药物了,泰国首都曼谷自从1977年报告2例产生青霉素酶淋球菌(PPNG)以后,用青霉素治疗无并发症淋病的失败率一直上升到1979年达到30%。1981年在曼谷分离的淋球菌属于PPNG菌株者占42.9～48.9%。因此,必须应用对PPNG和非-PPNG菌株均有高效的药物来治疗。除了壮观霉素以外,许多新的头孢菌素如头孢呋肟、头孢噻肟、头霉噻吩等均报告有很高的疗效,但均需肌注,而且疼痛。新药Rosoxacin为一种含吡啶基喹啉的衍生物。对
Penicillin is no longer the drug of choice for gonorrhea since the penicillin-producing gonococcus was discovered in 1976, and the failure to treat penicillin-free gonorrhea with penicillin has not been reported in Thailand’s capital, Bangkok, since 1977, when two cases of penicillinase-producing Neisseria gonorrhoeae (PPNG) were reported The rate has risen to 30% by 1979. Neisseria gonorrhoeae isolated in Bangkok in 1981 belonged to PPNG strains accounting for 42.9-48.9%. Therefore, treatment with PPNG and non-PPNG strains must be effective. In addition to spectinomycin, many new cephalosporins, such as cefuroxime, cefotaxime, and head-thymidine, have reported high efficacy but require intramuscular and painful pain. Rosoxacin, a new drug, is a derivative of pyridylquinoline. Correct