Ⅱ型糖尿病患者的黎明现象探讨

• 作 者: 郑白蒂 雷建文 周俊淇 钟学礼
• 机 构: 上海医科大学附属华山医院糖尿病研究室,上海医科大学附属华山医院糖尿病研究室,上海医科大学附属华山医院糖尿病研究室,上海医科大学附属华山医院糖尿病研究室
• 出 处: 中华内分泌代谢杂志
• 发表日期: 1990年03期
• 关键词: Ⅱ型糖尿病 血糖浓度 NIDDM 拮抗激素 黎明现象 睡眠状态 高血糖 口服降糖药 糖基化血红蛋白 血糖波动

本文对10例NIDDM进行了黎明现象测试,受试者于午夜至6:00～6:30a.m.保持睡眠状态,0:30～8:00a.m.每30分钟采血一次,作FBG、血浆INS、GH(自0a.m.开始采血)、F、E、NE及血清TT_3测定。结果示FBG于4:00a.m.后开始上升,于7:00a.m.达最高值;INS于0～5:00a.m.逐渐下降,且与增高的血糖浓度无相关。0a.m.时的GH高峰值与增高的血糖浓度成正相关。F(3:00a.m.后)、NE、E(4:00a.m.后)分泌浓度均呈有意义的增高,但与增高的血糖浓度均无相关。

In this paper, 10 cases of NIDDM dawn phenomenon test subjects in midnight to 6: 00 ~ 6: 30 a.m. Sleep, 0: 30 ~ 8: 00 a.m.All blood samples every 30 minutes for FBG, Plasma INS, GH (blood collected since 0 a.m.), F, E, NE and serum TT_3 were measured. The results showed that FBG began to rise after 4:00 a.m. and reached the maximum at 7:00 a.m. INS gradually decreased from 0 to 5:00 a.m. and was not related to the elevated blood glucose level. The peak value of GH at 0a.m. was positively correlated with increased blood glucose concentration. F (3:00 a.m.after), NE, E (4:00 a.m.) secreted concentrations were significantly increased, but not with increased blood glucose concentrations were not related.