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摘要目的人群中乳腺密度的差异可以部分解释地区间乳腺癌筛查效能的变化。本研究旨在明确荷兰筛查的人口中是否存在乳腺密度分布的地区性差异。方法作为DENSE试验的一部分,使用一个完全自动化的容积法测量乳腺密度。研究在地理位置上覆盖了14个阅片单位,代表荷兰的很大一部分。采用一般线性模型进行数据分析。结果 2013年—2014年间,共48 5021名受试者参与筛查,中位年龄为60岁。不同区域中,32.5%~45.7%的女性具有非均质或极致密乳腺。平均密度体积介于6.51%(95%CI:6.46%~6.55%)和
Abstract Differences in breast density in the population of interest may partially explain the changes in screening efficacy of breast cancer in different regions. The aim of this study was to determine whether there is a regional difference in breast density distribution among populations screened in the Netherlands. Methods As part of the DENSE trial, a fully automated volumetric method was used to measure mammary density. The study has geographically covered 14 reading units, representing a large part of the Netherlands. General linear model for data analysis. Results Between 2013 and 2014, a total of 482,021 subjects participated in the screening, with a median age of 60 years. In different regions, 32.5% ~ 45.7% of the women have heterogeneous or very dense breasts. The average density volume was between 6.51% (95% CI: 6.46% ~ 6.55%) and