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目的:探讨新型标志物HAb18G/CD147在胃癌组织中的表达及其与临床病理学的关系。方法:收集手术切除的胃癌样本552例,构建组织芯片,并以100例癌旁正常胃黏膜组织作为对照。利用免疫组化方法检测2组HAb18G/CD147的抗原表达和定位,并追踪随访胃癌组患者12～72个月。结果:HAb18G/CD147抗原定位于细胞膜,在胃癌组织中表达阳性率高于癌旁正常胃黏膜组织(63%比55%)。肿瘤组织中HAb18G/CD147的高表达与肿瘤大小、Borrmann分型、Lauren组织学分型、肿瘤浸润深度、淋巴结转移及TNM分期密切相关(P<0.05),但与患者的年龄、性别、肿瘤生长部位、肿瘤分化程度、有无脉管浸润及远处转移间无相关性(P>0.05)。HAb18G/CD147阳性表达与患者术后近期生存率显著相关(P=0.023)。结论:HAb18G/CD147在胃癌中的表达与胃癌的发展、侵袭性行为及预后均相关,可作为临床评估胃癌生物学行为不良的一项分子标志。
Objective: To investigate the expression of novel marker HAb18G / CD147 in gastric carcinoma and its relationship with clinicopathology. Methods: A total of 552 gastric cancer specimens were collected. Tissue microarrays were constructed and 100 normal gastric mucosa adjacent tissues were used as control. Immunohistochemistry was used to detect the antigen expression and localization of HAb18G / CD147 in two groups. The patients were followed up for 12 to 72 months. Results: The positive rate of HAb18G / CD147 antigen in the cell membrane was higher than that in normal gastric mucosa (63% vs 55%). High expression of HAb18G / CD147 in tumor tissues was closely related to tumor size, Borrmann type, Lauren histological type, depth of tumor invasion, lymph node metastasis and TNM stage (P <0.05), but not with age, sex, tumor growth site , Tumor differentiation, presence or absence of vascular invasion and distant metastasis (P> 0.05). The positive expression of HAb18G / CD147 was significantly correlated with the postoperative survival rate of patients (P = 0.023). Conclusion: The expression of HAb18G / CD147 in gastric cancer is related to the development of gastric cancer, invasive behavior and prognosis, which may be used as a molecular marker for clinical evaluation of biological behavior of gastric cancer.