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目的 :探讨反流性食管炎 (Reflaxesophagitis,RE)的食管动力学改变特征及反流性食管炎的发生机理。方法 :使用高分辨的多道灌注测压系统 (PCpolrrafHR瑞典产 )测定了 12例正常人及反流性食管炎患者 2 8例的食管压力。结果 :RE组食管下括约肌 (LES)静息压 (2 41± 0 87kPa)明显低于正常对照组 (3 0 3± 0 6 2kPa) ,食管体蠕动波幅 (2 81± 0 43kPa)明显低于正常对照组 (3 2 3± 0 6 2kPa) ,食管体部运动异常检出率 (71 43% )明显高于对照组 (16 6 7% ) ,差异均有显著性 (p <0 0 5 ) ;下食管括约肌长度 (3 11± 0 47cm)与正常组 (3 35± 0 34cm)比较 ,差异均无显著性 (p >0 0 5 )。结论 :LES压力低下 ,食管运动功能紊乱、LES的松驰可能在RE的发病中起重要的作用。食管测压检查有助于发现食管动力异常和探讨反流性食管炎的发生机制
Objective: To investigate the esophageal dynamic changes and the pathogenesis of reflux esophagitis with Reflax esophagitis (RE). METHODS: Esophageal pressure was measured in 28 normal subjects and 28 patients with reflux esophagitis using a high-resolution multichannel perfusion manometry system (PCpolrrafHR Sweden). Results: Resting pressure (2 41 ± 0 87 kPa) in lower esophageal sphincter (RE) group was significantly lower than that of normal control group (3 0 3 ± 0 6 2 kPa), and amplitude of peristalsis was significantly lower than that of esophageal body (2 81 ± 0 43 kPa) The detection rate of abnormal esophageal motility in the normal control group (3223 ± 0 62kPa) was significantly higher than that in the control group (71 43%) (p <0.05) ; The length of the lower esophageal sphincter (3 11 ± 0 47cm) was not significantly different from that of the normal group (35 35 ± 0 34cm) (p 0 05). CONCLUSION: LES stress is low and esophageal motor function is disturbed. Relaxation of LES may play an important role in the pathogenesis of RE. Esophageal manometry helps to detect esophageal motility abnormalities and to explore the mechanism of reflux esophagitis