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目的:探讨糖化血红蛋白参考阈值在糖尿病一级预防中的应用价值。方法:检测重点人群糖化血红蛋白,按结果分为四个区间;根据WHO(1999)糖尿病诊断标准分区间试验,并分为五型糖耐量并统计学处理。结果:凉州区重点人群糖尿病发病率为27.4%,糖调节受损发病率为53.1%。在6.0%≤HbA1C<6.5%区间其糖尿病发病率明显高于5.0%≤HbA1C<6.0%区间。前者糖调节受损发病率69.8%。后者71.2%。前者以空腹血糖受损与DM发病为主占32.3%与28%,后者以糖耐量受损发病为主占58.4%。强化生活方式干预五年,糖尿病发病率下降42.9%。结论:在6.0%≤HbA1C<6.5%区间以干预、治疗空腹血糖受损与筛查DM为主。在5.0%≤HbA1Cc<6.0%区间以干预、治疗糖耐量受损为主。强化生活方式干预对预防糖尿病具决定性作用。
Objective: To investigate the reference value of glycosylated hemoglobin in the prevention of primary diabetes mellitus. Methods: HbA1c was detected in key populations and divided into four intervals according to the results. According to WHO (1999) diagnostic criteria for diabetes mellitus, the patients were divided into five types of IGTs and statistically analyzed. Results: The incidence of diabetes was 27.4% and the incidence of impaired glucose regulation was 53.1% in key population of Liangzhou District. The incidence of diabetes in the range of 6.0% ≤HbA1C <6.5% was significantly higher than 5.0% ≤HbA1C <6.0%. The former impaired the incidence of impaired glucose regulation 69.8%. The latter 71.2%. The former with fasting blood glucose and DM incidence accounted for 32.3% and 28%, which impaired glucose tolerance mainly accounted for 58.4%. Intensified lifestyle intervention for five years, the incidence of diabetes decreased by 42.9%. Conclusion: Intervention in the range of 6.0% ≤HbA1C <6.5%, treatment of impaired fasting glucose and screening of DM-based. Intervention in the range of 5.0% ≤HbA1Cc <6.0%, the treatment of impaired glucose tolerance. Strengthening lifestyle interventions have a decisive role in the prevention of diabetes.