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一氧化氮(NO)是一个简单的气体自由基,在心血管、免疫和神经系统是一个重要的信号分子.NO由不同形式的NO合酶,内皮型NO合酶(eN OS),神经型NO合酶(n NOS)和诱导型NO合酶(iN OS)在不同细胞中产生.NO在调节血压和血管稳态方面发挥重要的生理作用,但是,由i NOS产生过量的NO就会抑制心脏收缩、损伤线粒体甚至引起细胞凋亡.NO可以影响神经递质释放及突出体生成过程和可塑性,NO在脑的发育和维持调节脑回路、作为学习的信号分子发挥着重要作用.然而,越来越多的证据表明,如果NO产生过多,就可能损伤心血管和神经,甚至引起心脑血管还推行型疾病.该文综述了近年来利用ESR研究NO在心脑血管疾病和健康方面的“双刃剑”作用和天然抗氧化剂的保护作用的一些结果.
Nitric oxide (NO) is a simple gas free radical that is an important signaling molecule in the cardiovascular, immune and nervous systems.NO consists of various forms of NO synthase, eNOS, neuronal NO Synthetic synthase (nNOS) and inducible NO synthase (iNOS) are produced in different cells. NO plays an important physiological role in the regulation of blood pressure and vascular homeostasis, but excessive production of NO by iNOS suppresses the heart Contraction and damage mitochondria and even cause apoptosis.NO can affect neurotransmitter release and process of protrusion formation and plasticity, NO plays an important role as a learning signal molecule in the development of the brain and maintaining the regulation of the brain circuit.However, The more evidences show that if excessive production of NO, it may damage the cardiovascular and nerve, and even lead to cardio-cerebrovascular also push diseases.In this paper, the use of ESR in recent years to study the NO in cardiovascular disease and health Some results of the “double-edged sword” effect and the protective effect of natural antioxidants.