A Novel Pharmacophore Model Derived from a Class of Capsid Protein Enterovirus 71 Inhibitors

• 作 者: DUAN Hong-Xia YANG Xin-Ling WA
• 机 构: DepartmentofAppliedChemistry,InstituteofPlantProtection,DepartmentofPathophysiology
• 出 处: 结构化学
• 发表日期: 2012年8期
• 关键词: 药效团模型 酶抑制剂 衣壳蛋白 肠病毒 预测能力 生物活性 分子结构 活性位点 capsid protein enterovirus 71 inhibitor；
• 基金项目: Sponsored by the National Natural Science Foundation of China （No. 30800719）

Capsid protein enterovirus 71 (EV71) is one of the major viruses that cause the severe encephalitis and thus result in a high mortality in children less than 5 years of age.In an effort to discover new potent inhibitors against EV71,a novel three-dimensio