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对１０６例细菌性阴道炎进行药物治疗的前瞻性双盲研究。其中试验组６６例，应用环丙沙星泡腾片；对照组４０例，应用氟哌酸栓剂。结果：在病情缓解、粘膜充血度和白带清洁度改善方面，两组间疗效相近（Ｐ＞０．０５）；细菌性阴道炎常见致病菌为肠道菌群和葡萄球菌属，对肠道菌群，两药均有很高抗菌活性，治疗后细菌阴转率分别为９３．３３％和９４．４４％，无显著差异（Ｐ＞０．０５）；对葡萄球菌属，试验组细菌阴转率为９５．８３％，对照组为６０％，差异显著（Ｐ＜０．０１）；总疗效分析，试验组为８９．４０％，对照组为７５％，有差异（Ｐ＝０．０５）；血、尿常规检查治疗前、后无显著差异；无明显副作用。提示：随着氟哌酸的广泛应用，耐药菌株在逐渐增多，环丙沙星泡腾片可望成为治疗细菌性阴道炎的首选药物。
A prospective, double-blind study of 106 patients with bacterial vaginosis treated with drugs. The experimental group of 66 cases, the application of ciprofloxacin effervescent tablets; control group of 40 cases, the application of norfloxacin suppository. Results: The curative effect was similar between the two groups (P> 0.05). The common pathogens of bacterial vaginosis were intestinal flora and Staphylococcus, The bacterial population and the two drugs have high antibacterial activity. After treatment, the bacterial negative conversion rates were 93.33% and 94.44% respectively, with no significant difference (P> 0.05). For Staphylococcus, (P <0.01). The total effective rate was 89.40% in the test group and 75% in the control group (P = 0.05) ); Blood, urine routine examination before and after treatment no significant difference; no significant side effects. Tip: With the widespread use of norfloxacin, drug-resistant strains are gradually increasing, ciprofloxacin effervescent tablets is expected to become the drug of choice for the treatment of bacterial vaginosis.