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本文前瞻性研究多次输血患者自然杀伤细胞功能及辅助/抑制(T_4/T_3)淋巴细胞比率,并与其他获得性免疫缺陷群体在危险因素方面予以比较。通过T细胞HLA-DR表现度和T淋巴细胞活力值寻找慢性免疫激活的证据。研究对象:正常对照50例(平均年龄31±8岁),病人包括32例镰状细胞病(30±7岁),29例β-地中海贫血(16±9岁),12例铁粒幼和特发性难治性贫血(38±24岁)及6例血友病A(32±11岁)。结果:效应细胞与靶细胞比率为100∶1时,输血患者外周血自然杀伤细胞活力明显低于正常对照(P<
This study prospectively investigated natural killer cell function and T_4 / T_3 lymphocyte ratio in multiple transfusions and compared risk factors with other acquired immunodeficient populations. Evidence of chronic immune activation is sought by T cell HLA-DR proficiency and T lymphocyte viability. Participants: 50 normal controls (mean age 31 ± 8 years), including 32 patients with sickle cell disease (30 ± 7 years), 29 patients with β-thalassemia (16 ± 9 years), 12 children with iron granules Idiopathic refractory anemia (38 ± 24 years) and hemophilia A (32 ± 11 years). Results: When the ratio of effector cells to target cells was 100: 1, the viability of natural killer cells in peripheral blood of transfusion patients was significantly lower than that of normal control (P <