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作者应用改良的 Gutman 和 Gutman 二氏法,以磷酸苯二钠的醋酸盐缓冲液为基质,测定了一组由于不同原因而引起的儿童血小板減少症(血小板少于15万/mm~3)的血浆酸性磷酸酶值。结果:在6例急性血小板减少症患者(4例为自发性,1例为奎尼丁中毒,1例为疹后)中,血浆酸性磷酸酶值均高于其年龄的平均值。骨髓检查证实均具有明显的多核巨细胞增生。当得到适当治疗而血小板增加时,血浆酸性磷酸酶亦即下降。在15例慢性自发性血小板減少性紫瘢患者中,有13例血浆酸性磷酸酶增高,两例低于其年龄平均值,均对脾切除有反应,显示多核巨细胞增生。
The authors used modified Gutman’s and Gutman’s’s method to determine a group of children with thrombocytopenia (platelets less than 150,000 / mm ~ 3) due to different causes, taking acetate dibasic sodium acetate buffer as matrix. Plasma acid phosphatase value. Results: In 6 patients with acute thrombocytopenia (4 were spontaneous, 1 was quinidine poisoning, 1 was rash), plasma acid phosphatase values were higher than their average age. Bone marrow examination confirmed significant multinucleated giant cell hyperplasia. When properly treated platelets increase, plasma acid phosphatase that is reduced. Of the 15 patients with chronic idiopathic thrombocytopenic purpura, 13 had elevated plasma acid phosphatase, both of which were below the mean of their age and responded to splenectomy, indicating multinucleated giant cell hyperplasia.