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在多数中心治疗肢端肥大症,首选垂体切除术。然而对不适合手术或手术不能提供生长激素(GH)足够控制的患者,需第二线有效的治疗。本文分析用兆伏外照射长期治疗肢端肥大症患者,特别是观察其效果和副作用的结果。 研究27名患者,男12,女15,均有肢端肥大症典型临床特征,在100g葡萄糖耐量试验不能将GH水平控制到<2mU/l者作为诊断。标准采用放射免疫法测GH。25例在26～30天由12或13次照射靶剂量3600～4000cGy(即每周3次共4周),1例在4周内20次照射用较高的4800cGy;1例在28天内12次照射4320 cGy。照射后5例,垂体切除后2例和死后3
In most centers for the treatment of acromegaly, the preferred pituitary surgery. However, patients who are not suitable for surgery or surgery that do not provide adequate control of growth hormone (GH) require second-line treatment. This article analyzes the long-term treatment of acromegaly patients with mega-volt external irradiation, in particular, the results of observation of its effects and side effects. Twenty-seven patients, male 12 and female 15, had typical clinical features of acromegaly and were not diagnosed when GH levels were <2 mU / l in a 100 g glucose tolerance test. Standard radioimmunoassay GH. Twenty-five of the 25 patients received 3600-4000 cGy of target doses (ie, three times a week for 4 weeks) from 12 or 13 exposures on 26-30 days, 1 4800 cGy for 20 doses over a 4-week period and 4800 cGy for 1 patient over 28 days 4320 cGy times. 5 cases after irradiation, 2 cases after pituitary resection and 3 after death