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补体C4与B因子基因位于人类主要组织相容性复合体(MHC)Ⅰ、Ⅱ类基因之间,它们与HLA-Ⅰ、Ⅱ类抗原一样,可组合成多种单体型。作者在原来研究中发现C4与B因子所组成的单体型在青年人中出现的频率与在老年人中出现的频率有明显的不同,本文比较C4、B因子的各等位基因在不同年龄组中的分布.作者对252名(男性122,女性130) 45岁以下(青年组)、482名(男性194,女性288) 60～90岁(老年组)和100名(男性36,女性84)90岁以上的人作了C4和B因子定型。结果发现,Ef~*F在老年组
Complement C4 and factor B genes are located between the major human histocompatibility complex (MHC) class I and class II genes. Like the HLA class I and class II antigens, they can be combined into multiple haplotypes. In the original study, the authors found that the frequency of haplotypes composed of C4 and B factors in young people is significantly different from that in older people. This study compared the alleles of C4 and B factors at different ages. Distribution in the group. Authors of 252 (male 122, female 130) under 45 (youth group), 482 (male 194, female 288) 60 to 90 (elderly group) and 100 (male 36, female 84 ) People over the age of 90 made C4 and B factor stereotypes. The results found that Ef ~ * F in the elderly group