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胸腺对免疫系统的发生与形成起决定性作用。生理方面,从原始无活性的前T细胞到免疫活性T淋巴细胞的成熟过程发生在胸腺内;对自身主要组织相容性复合体决定簇的识别能力也在胸腺内获得。病理方面,T细胞淋巴瘤是在胸腺内发生的。现已知,体液因子影响胸腺内T细胞分化的某些过程。但是,T细胞发育分化的某些过程无疑是需要分化及迁移着的胸腺细胞与胸腺基质的固有成分之间相互作用。本文就近来对T淋巴细胞在胸腺内发育分化以及迁移研究的某些资料归述如下。
Thymus plays a decisive role in the occurrence and formation of the immune system. Physiologically, the maturation process from primed, inactive pre-T cells to immunocompetent T-lymphocytes takes place in the thymus; the ability to recognize its own major histocompatibility complex determinant is also obtained in the thymus. Pathologically, T-cell lymphoma occurs in the thymus. It is known that humoral factors affect certain processes of T cell differentiation in the thymus. However, certain processes of T cell development and differentiation undoubtedly require the interaction between the differentiated and migratory thymocytes and the intrinsic components of the thymus stroma. This article on the recent development of T lymphocytes in the thymus differentiation and migration of some of the data described below.