论文部分内容阅读
组织血管紧张素生成取决于从循环中获取的肾素(肾脏生成)和(或)肾素前体(统称为肾素原)。鉴于组织中血液的容量(含肾素血液),组织中所含的肾素原水平通常高于预期,推断可能存在一种主动的肾素转运机制。发现于2002年的肾素原受体(prorenin receptor,PRR)似乎是一个有重要意义的候选作用机制,尽管该受体与肾素/肾素原亲和力高于其在血液中水平许多数量级。该文讨论自PRR发现以来的相关
Tissue angiotensin production depends on renin (kidney production) and (or) renin precursors (collectively, renin) obtained from the circulation. Given the volume of blood in the tissue (including renin blood), the levels of renin contained in tissues are usually higher than expected, suggesting that there may be an active renin transport mechanism. The prorenin receptor (PRR), found in 2002, appears to be an important candidate mechanism of action, although it has many orders of magnitude higher affinity for renin / renin than it does in blood. This article discusses the correlation since PRR discovery