论文部分内容阅读
20年前的氨苄青霉素和近年生产的羟氨苄青霉素都已用于治疗呼吸道感染。虽然两种药物在相同血药浓度时的临床作用有所不同,但不同研究方法所得的大量报道均认为羟氨苄青霉素在痰中的浓度比氨苄青霉素高。对同一病人同时用两种药物后分别对其检测是一种新的研究方法,它允许在同一样本中对两种不同药物进行比较。作者用该方法研究了5例严重慢性支气管炎病人同时静注羟氨苄青霉素和氨苄青霉素后的血清药代动力学和在痰中的渗透能力。5例病人均为
Ampicillin 20 years ago and amoxicillin that have been produced in recent years have been used to treat respiratory infections. Although the clinical effects of the two drugs at the same plasma concentration are different, numerous reports from different studies suggest that amoxicillin is more concentrated in sputum than ampicillin. Testing the same patient with both drugs at the same time is a new method of study that allows for the comparison of two different drugs in the same sample. The authors used this method to study the serum pharmacokinetics and the ability to penetrate sputum in five patients with severe chronic bronchitis treated with intravenous ampicillin and ampicillin. 5 patients were