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Background The aim of this review was to summarize and identify the variations in the effectiveness of psychological interventions on adherence,metabolic control,and coping with stress in adolescents with type 1 diabetes (T1D).Methods An electronic search of literature was performed using PubMed (NLM),Embase (Ovid),CINAHL Plus (EBSCO-host),PsycINFO (Ovid),and Google Scholar.The search was limited to include articles reported the effect of one of the psychological interventions: cognitive behavioral therapy (CBT),coping skills training (CST),stress management,or psychotherapy intervention.The report included peer-reviewed articles published in English from January 1990 until May 2019in adolescents with T1D,and summarizes the results of 24 studies that met the inclusion criteria.Results Psychological interventions showed differential effects on adherence,metabolic control,and coping with stress in adolescents with T1D.Behavioral interventions using principles of CBT appear to have a superior positive effect on regimen adherence compared with other types of psychological protocols.In contrast,metabolic control was significantly improved with the implementation of CST and some forms of CBT.Stress management and psychotherapy interventions showed significant promises for adolescents to cope with their diabetes-related daily stressors.Conclusions However,the findings may add some promises to diabetes management in adolescents,additional research to understand the effect of these interventions is needed.