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目的:探讨乳腺癌钼靶钙化征象与雌激素受体(Estrogen receptor,ER)、孕激素受体(progesterone receptor-PR)、抑癌基因(P53)表达的相关性。方法:回顾分析96例术后病理组织学证实乳腺癌钙化情况与肿瘤细胞ER、PR及P53表达的免疫组化的相关性。结果:钙化形态、钙化点的总数与ER、PR、P53表达无明显相关性(P>0.05)。钙化的分布密度(N/S)>20枚/cm2组ER、PR、P53阳性表达率均略高于钙化灶≤20枚/cm2组,但差异无统计学意义。结论:钙化分布不同的乳腺癌之间P53表达有统计学差异,因此可以通过钙化分布来预测P53的表达。钙化形态、钙化点的总数、钙化的分布密度与ER、PR、P53无相关性,因此不能通过钙化形态、钙化点的总数、钙化的分布密度来预测ER、PR、P53的表达。
Objective: To investigate the correlation between the mammographic signs of breast cancer and the expression of estrogen receptor (ER), progesterone receptor-PR and tumor suppressor gene (P53). Methods: A retrospective analysis of 96 cases histopathologically confirmed breast cancer calcification and ER, PR and P53 expression of immunohistochemical correlation. Results: There was no significant correlation between the total number of calcification and calcification (P> 0.05) and ER, PR and P53 expression. The positive expression rates of ER, PR and P53 in calcification with distribution density (N / S)> 20 / cm2 were slightly higher than those with calcification ≤20 / cm2, but the difference was not statistically significant. CONCLUSIONS: There is a statistically significant difference in P53 expression between different breast cancer tissues, so P53 expression can be predicted by calcification. Calcification, total calcification, calcification distribution density and ER, PR, P53 no correlation, it can not through the calcification morphology, the total number of calcification, calcification distribution density to predict ER, PR, P53 expression.