重症肝炎Glucagon-Insulin疗法滴注前后血中胰岛素、胰升血糖素等浓度变化

• 作 者: 孟令先 刘沛 董祥家 李彦卿 金玉珠
• 机 构: 中国医科大学附属第三医院肝炎研究室,中国医科大学附属第三医院肝炎研究室,中国医科大学附属第三医院肝炎研究室,沈阳市传染病院,沈阳市传染病院
• 出 处: 中国医科大学学报
• 发表日期: 1988年03期
• 关键词: 胰升血糖素 胰岛素剂量 胰高血糖素 C肽 肝活检 Insulin 前后血 代谢情况 glucagon 降解功能

经肝活检证实的重症肝炎11例,在胰高血糖素-胰岛素(G-I)疗法前及滴完后15、30、60、120、180分钟采血,检测血清糖、胰岛素、C肽及血浆胰升血糖素。结果:血糖在滴注前正常或偏低,滴后轻度上升即降至滴前水平;胰岛素、C肽及胰升血糖素滴前均高于正常,滴后15分钟高峰,滴后3小时C肽及胰升血糖素恢复到滴前水平,而胰岛素持续呈高值。可见重症肝炎对胰岛素的摄取和降解功能降低,而对胰升血糖素有摄取和降解功能。

Eleven patients with severe hepatitis confirmed by liver biopsy were collected before and after 15, 30, 60, 120 and 180 minutes after glucagon-insulin therapy. Serum glucose, insulin, C-peptide and plasma pancreatic ascending Glucagon Results: Before or after instillation, blood glucose was normal or low, dropping slightly to the level before dripping. Insulin, C peptide and glucagon dripping were higher than normal before dripping, 15 minutes after dripping, 3 hours after dripping C peptide and glucagon returned to pre-drip levels, while insulin sustained high values. Severe hepatitis can be seen on the insulin intake and degradation of reduced function, and glucagon intake and degradation of the function.