Synthesis and characterization of insulin-5-Fu conjugate,enabling insulin as multi-drug carrier via

• 出 处: Chinese Chemical Letters
• 发表日期: 2007年03期
• 关键词: conjugate solubility enabling linker branch enable residues Fluorouracil hydroly

To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-Fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.

To enable insulin as multi-drug carrier, we designed and synthesized dendritic linker molecule bearing three 5-Fluorouracil residues at the branch ends. The new conjugate showed excellent water solubility. The stabilities under different conditions were investigated. The results showed that the conjugate was a potential prodrug to release free 5-Fu.