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ED患者服用5-磷酸二酯酶抑制剂西地那非后出现的心脏不良事件引起人们对缺血性心脏病患者使用西地那非安全性的关注。为此,Reffelmann T等进行动物实验考查西地那非对缺血性心脏病的可能影响。在麻醉后开胸兔发生缺血前30min,静注西地那非1．45mg/kg或生理盐水(每组12例),在冠脉堵塞后30min或再灌注发生180后检测梗死范围、无再灌注范围和局部心肌血供。另设每组5例以使用超声心动描记术检测左心室血流动力学及其各径线的变化。结果显示,西地那非在冠脉阻断之前能明显降低血
Adverse cardiac events after ED patients taking 5-phosphodiesterase inhibitor sildenafil have raised concerns about the safety of sildenafil in patients with ischemic heart disease. To this end, Reffelmann T and other animal experiments to investigate the possible impact of sildenafil on ischemic heart disease. Thirty minutes before ischemia in the open thoracotomy rabbits, intravenous sildenafil 1.45 mg / kg or saline (12 in each group), infarct size was detected 30 min after coronary occlusion or 180 reperfusion Reperfusion range and regional myocardial blood supply. Another set of 5 cases for each group to use echocardiography to detect left ventricular hemodynamics and changes in its diameter line. The results show that sildenafil can significantly reduce blood before coronary artery occlusion