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目的研究多发性硬化(MS)患者抑郁的发生率、特点及其相关因素。方法通过汉密尔顿抑郁量表(Hamiltondepression,HAMD)了解作者医院32例MS患者的抑郁状况,进而以扩展残疾状况评分(expandeddisabilitystatusscale,EDSS)评估其神经功能缺损程度,并与其他神经免疫性疾病患者、非免疫性中枢神经系统疾病患者和健康者各30名进行比较;同时分析MS患者年龄、性别、病程、EDSS评分与患者抑郁的相关性。结果MS患者抑郁的发生率为436%,明显高于各对照组;患者神经功能缺损程度与抑郁呈正相关;MS患者年龄、性别、病程与抑郁无明显相关。结论MS患者抑郁发生率很高,应引起临床关注;抑郁的发生可能与其中枢神经系统病灶及免疫学异常有关。
Objective To study the incidence, characteristics and related factors of depression in patients with multiple sclerosis (MS). Methods The depression status of 32 patients with MS in the author hospital was studied by the Hamilton Depression Scale (HAMD), and then the extent of neurological deficits was evaluated by the expanded disability status scale (EDSS), and compared with other neuroimmune disease patients, 30 patients with immune diseases of central nervous system and healthy persons were compared for each other. At the same time, the correlation between age, sex, duration of disease, EDSS score and depression was analyzed. Results The incidence of depression in MS patients was 436%, which was significantly higher than that in control groups. The degree of neurological deficits was positively correlated with depression. There was no significant correlation between age, sex, duration of disease and depression in MS patients. Conclusions MS patients with high incidence of depression should cause clinical concern; the occurrence of depression may be related to its central nervous system lesions and immunological abnormalities.