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目的观察奥沙利铂与替加氟治疗晚期胃癌的临床疗效。方法随机选取2014年6月至2016年6月我院收治的晚期胃癌患者26例,患者均在第一天静滴奥沙利铂130mg/m~2,时间为2h;第1-5天使用微量泵静脉输入替加氟600mg/m~2,24h持续泵入。3至4周为一周期,连续治疗2个周期后,对治疗效果进行评价。结果 26例患者中,CR 0例,PR 15例(57.7%),NC 7例(26.9%),PD 4例(15.4%),治疗总有效率为57.7%。中位缓解期与生存期分别为5.1个月、7.9个月,临床受益率86.4%。患者治疗期间主要出现脱发、呕吐、神经毒性、以及腹泻等毒副反应。结论奥沙利铂与替加氟联合治疗晚期胃癌临床效果显著,毒副反应程度较轻,都在患者耐受范围之内,提高了患者生存质量,是晚期胃癌的有效治疗方案,值得在临床推广应用。
Objective To observe the clinical efficacy of oxaliplatin and tegafur in the treatment of advanced gastric cancer. Methods Twenty-six patients with advanced gastric cancer who were admitted to our hospital from June 2014 to June 2016 were selected randomly. Patients were given oxaliplatin 130 mg / m 2 intravenously on the first day for 2 hours. The first 1-5 days Micropump intravenous infusion of tegafur 600mg / m ~ 2,24 h continuous pump. Three to four weeks for a cycle, continuous treatment of two cycles, the treatment was evaluated. Results Of the 26 patients, CR 0, PR 15 (57.7%), NC 7 (26.9%) and PD 4 (15.4%) had a total effective rate of 57.7%. The median remission and survival were 5.1 months and 7.9 months respectively, and the clinical benefit rate was 86.4%. Mainly during the treatment of patients with hair loss, vomiting, neurotoxicity, and diarrhea and other toxic side effects. Conclusion The combination of oxaliplatin and tegafur is effective in the treatment of advanced gastric cancer. The clinical effect of oxaliplatin in combination with tegafur is significant. Promote the application.