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多囊卵巢病的主要特征是循环LH水平升高而FSH释放减少。给这类患者静脉注射多巴胺可明显降低循环LH水平。用左旋多巴治疗一周,也可使患者对GnRH兴奋试验的LH反应明显低于治疗前及正常受试者。溴隐亭是一种极强的多巴胺激动剂,可使某些多囊卵巢病患者的LH水平降低并恢复规律的排卵机能。本文评价溴隐亭对多囊卵巢病患者促性腺激素及甾体分泌的影响,仔细观察其急性及慢性反应并与临床结果进行比较。
The main features of polycystic ovarian disease is elevated circulating LH levels and reduced FSH release. Intravenous injection of dopamine into such patients can significantly reduce circulating LH levels. Treatment with levodopa for one week also resulted in a significantly lower LH response for GnRH stimulation compared with pre-treatment and normal subjects. Bromocriptine is a potent dopamine agonist that reduces LH levels and regains regular ovulation in some patients with polycystic ovary disease. This article evaluates the effect of bromocriptine on gonadotropin and steroid secretion in patients with polycystic ovary disease. The acute and chronic reactions were carefully observed and compared with clinical results.