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建立了血中华法林对映体的毛细管电泳分析方法。电泳缓冲液由１４０ｍｍｏｌ／Ｌ磷酸盐缓冲液和７ｍｍｏｌ／Ｌ的甲基β－环糊精组成（ｐＨ７．９）。工作电压１３ｋＶ，检测波长２１０ｎｍ。两种对映体Ｓ（－）－华法林及Ｒ（＋）－华法林达到基线分离，在０～５μｇ／ｍｌ范围内呈线性。血中华法林对映体最低检测浓度均为０．０２μｇ／ｍｌ，精密度及回收率均较好。
A capillary electrophoresis method was developed for the determination of warfarin enantiomers in blood. The electrophoresis buffer consisted of 140 mmol / L phosphate buffer and 7 mmol / L methyl β-cyclodextrin (pH 7.9). Working voltage 13kV, detection wavelength 210nm. The two enantiomers S (-) - warfarin and R (+) - warfarin baseline separation, in the 0 ~ 5μg / ml range was linear. The minimum detectable concentration of warfarin enantiomer in blood was 0.02μg / ml, and the precision and recovery rate were good.