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目的探讨系统性红斑狼疮(SLE)合并急性胰腺炎的临床特点、病因、发病机制和治疗方法。方法回顾性分析1983-01～2003-03北京协和医院住院治疗的SLE合并急性胰腺炎患者15例。结果急性轻型胰腺炎12例,重型胰腺炎3例。所有患者均给予中到大剂量糖皮质激素治疗,病情痊愈5例,好转5例,死亡5例。结论(1)急性胰腺炎是SLE病情活动的表现;(2)胰腺血管病变是导致胰腺炎的主要致病机制;(3)糖皮质激素可能不是导致胰腺炎的病因;(4)中到大剂量糖皮质激素治疗是安全有效的。
Objective To investigate the clinical features, etiology, pathogenesis and treatment of systemic lupus erythematosus (SLE) complicated with acute pancreatitis. Methods A retrospective analysis of 15 patients with SLE complicated with acute pancreatitis admitted to Peking Union Medical College Hospital from January 1983 to March 2003 was performed. Results 12 cases of acute pancreatitis and 3 cases of severe pancreatitis. All patients were given medium to large doses of glucocorticoid therapy, the disease recovered in 5 cases, improved in 5 cases, 5 died. Conclusions (1) Acute pancreatitis is a manifestation of SLE disease activity; (2) Pancreatic vascular disease is the main pathogenic mechanism leading to pancreatitis; (3) Glucocorticoid may not be the cause of pancreatitis; (4) Medium to large Dose glucocorticoid treatment is safe and effective.