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目的观察伊曲康唑在治疗深部真菌感染中的疗效及不良反应,进一步探讨其应用价值。方法回顾性分析2007年1月～2011年1月就诊于某科的深部真菌感染并采用伊曲康唑治疗的病例60例,总结其疗效、不良反应等情况。结果 60例患者拟诊真菌感染17例,临床诊断39例,确诊4例;60例患者中3例因不良反应而停药,1例因经济原因中断治疗,其余56例患者中治疗有效39例(69.6%),无效17例(30.4%);感染部位以呼吸道为主,易感因素包括粒缺、恶性肿瘤、化疗、激素及免疫抑制剂;感染病原体以白色念珠菌为主;治疗不良反应包括胃肠道症状、窦性心动过速、左心衰竭、肝功能损伤,停药后明显缓解。结论伊曲康唑是治疗深部真菌感染的有效药物,安全、经济、应用方便,值得临床广泛应用。
Objective To observe the efficacy and adverse reactions of itraconazole in the treatment of deep fungal infection and to explore its application value. Methods A retrospective analysis of 60 patients with deep fungal infection treated with itraconazole from January 2007 to January 2011 was performed. The curative effects and adverse reactions were summarized. Results Sixty patients were diagnosed as having fungal infection in 17 cases, 39 cases were diagnosed clinically, 4 cases were diagnosed, 3 cases were discontinued due to adverse reactions in 60 cases, one case was discontinued due to economic reasons, and 39 cases were treated in the remaining 56 cases (69.6%) and ineffective in 17 cases (30.4%). The main respiratory tract was respiratory tract. Susceptible factors included granuloma, malignant tumor, chemotherapy, hormones and immunosuppressive agents. Candida albicans was the main pathogen of infection. Adverse reactions Including gastrointestinal symptoms, sinus tachycardia, left heart failure, liver damage, withdrawal significantly relieved. Conclusion Itraconazole is an effective drug for the treatment of deep fungal infections. It is safe, economical and convenient for application. It is worthy of clinical application.