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非编码小分子RNA(miRNA)调节肝脏生物学功能,大量实验表明,小分子RNA(miRNA)对肝脏病理学中有作用。本文概述了miRNA在肝炎、肝硬化肝病领域的进展。microRNA-122是肝细胞中最丰富的微小RNA,在丙型肝炎病毒复制中起着非常明确的作用。实验数据显示,microRNA-122亦可作为一种可行性的靶向治疗。microRNA-122在其他肝脏疾病中亦有作用。大量研究证明,与肝炎有关的其他类型miRNA的重要调节潜力与酒精性肝炎、代谢综合征和自身免疫过程有关。此外,在动物模型和人类研究中,miRNA系列与肝脏纤维化进程有关联。miRNA在肝脏中的功能与细胞分布重要性以及miRNA潜在地作为细胞与器官联系纽带,循环miRNA作为肝损伤、肝癌疾病早期和进展的生物学标志,这些是值得我们讨论的。重要的是:miRNA在肝脏中的调节作用,代表着未来肝病治疗医疗技术中的一种新方法。
Non-coding small RNAs (miRNAs) regulate the biological functions of the liver. Numerous experiments show that small RNAs (miRNAs) play a role in liver pathology. This article outlines the progress of miRNA in hepatitis and cirrhosis. MicroRNA-122 is the most abundant microRNA in hepatocytes and plays a very clear role in hepatitis C virus replication. Experimental data show that microRNA-122 can also be used as a viable targeted therapy. MicroRNA-122 also plays a role in other liver diseases. Numerous studies have demonstrated that the important regulatory potential of other types of miRNAs associated with hepatitis is related to alcoholic hepatitis, metabolic syndrome and autoimmune processes. In addition, in animal models and human studies, the miRNA family is linked to the process of liver fibrosis. The importance of miRNA function and distribution in the liver as well as the potential role of miRNA as a cell to organ connection, circulating miRNA as a biomarker of liver injury and early and advanced liver cancer disease are worth discussing. Importantly, the regulatory role of miRNAs in the liver represents a new approach to medical technology in the future of liver disease.