兰屿树杞(Ardisia cf. elliptica)三萜及其抑制鸭(Anas platyrynchos L.)绒毛尿囊膜血管生成作用(英文)

• 作 者: Dennis D. Raga Annabelle A. Herrera Consolacion Y. Ragasa
• 机 构: Biology Department, School of Science and Engineering, Ateneo de Manila University,Institute of Biol
• 出 处: 中国天然药物
• 发表日期: 2013年02期
• 关键词: Ardisia cf 绒毛尿囊膜 elliptica 血管生成 capillary embryo viability survivability dried 兰

The dichloromethane extract of the air-dried leaves of Ardisia cf.elliptica(subgenus Tinus)afforded a mixture of bauerenol(1a),α-amyrin(1b)andβ-amyrin(1c).Their structures were identified by NMR spectroscopy.Mixtures of the triterpenes (1a-1c)at ratios of 2:2:1,2:2:3 and 1:1:1 were tested for their angio-suppressive effects on duck chorioallantoic membrane (CAM).All three ratios were found to be effective in restricting inter-capillary length,while 1a-1c(2:2:1)was most effective in reducing branch point density with 100%CAM viability and embryo survivability,suggesting a high impact angio-suppressive potential of 1a-1c(2:2:1).

The dimethyl extract of the air-dried leaves of Ardisia cf.elliptica (subgenus Tinus) afforded a mixture of bauerenol (1a), α-amyrin (1b) and β-amyrin (1c) .Their structures were identified by NMR spectroscopy. Mixtures of the triterpenes (1a-1c) at ratios of 2: 2: 1: 2: 3 and 1: 1: 1 were tested for their angio- suppressive effects on duck chorioallantoic membrane (CAM) effective in restricting inter-capillary length, while 1a-1c (2: 2: 1) was most effective in reducing branch point density with 100% CAM viability and embryo survivability, suggesting a high impact angio-suppressive potential of 1a-1c : 2: 1).