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随着乳腺癌发病率的增加,双侧乳腺癌的发病率也在逐年上升。Ki67作为目前较为肯定的细胞增殖标记物,与恶性肿瘤的增殖活性有关,它的表达对乳腺癌预后判断有重要意义。VEGF是一种重要的血管生成因子,在恶性肿瘤的形成中发挥重要的作用,与肿瘤的生长、浸润和转移有关。本文回顾及叙述了近几年来对Ki67和VEGF的研究及进展,包括二者的基本生物学特性,作用机理以及在双侧乳腺癌中的表达和临床分析。
As the incidence of breast cancer increases, the incidence of bilateral breast cancer is also increasing year by year. Ki67 as a more positive marker of cell proliferation, and the proliferation of malignant tumor activity, its expression of prognostic significance of breast cancer is of great significance. VEGF is an important angiogenic factor that plays an important role in the formation of malignant tumors, which is related to tumor growth, invasion and metastasis. This article reviews and describes the research and progress of Ki67 and VEGF in recent years, including the basic biological characteristics of both, the mechanism of action and the expression and clinical analysis in bilateral breast cancer.