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为证实促肝细胞生长素对重型肝炎肝细胞再生的促进作用,探讨血清甲胎蛋白(AFP)作为考核肝细胞再生指标的价值,作者对25例重型肝炎,在综合措施治疗的基础上加用促肝细胞生长素,观察AFP含量的变化,统计分析病死率,ALT及BiT复常时间,并与未采用促肝细胞生长素治疗的25例重型肝炎进行对比研究。结果治疗组治疗前与治疗后7天,14天,21天AFP含量对比,P<0.01。治疗组与对照组同期对比,P均<0.01。治疗组病死率、ALT和BiT复常时间对比,P分别<0.05、<0.01、<0.01。结论认为促肝细胞生长素治疗重型肝炎确有促进肝细胞再生作用,AFP作为考核重型肝炎肝细胞再生客观指标,有一定的参考价值。
In order to confirm the role of hepatocyte growth promoting factor in the promotion of hepatocyte regeneration in severe hepatitis and to explore the value of serum alpha-fetoprotein (AFP) as a marker of hepatocyte regeneration, 25 patients with severe hepatitis were treated with comprehensive treatment A hepatocyte growth hormone was induced to observe the change of AFP content. Statistical analysis of case fatality rate, ALT and BiT recovery time was made and compared with 25 cases of severe hepatitis without using hepatocyte growth-promoting factor. Results The AFP content in the treatment group before and 7 days, 14 days and 21 days after treatment was significantly lower than that before treatment (P <0.01). The treatment group and the control group over the same period, P <0.01. The treatment group mortality, ALT and BiT recovery time comparison, P <0.05, <0.01, <0.01. It is concluded that hepatocyte growth-promoting factor treatment of severe hepatitis does promote hepatocyte regeneration. AFP as an objective indicator of hepatocyte regeneration in severe hepatitis is of certain reference value.