论文部分内容阅读
实验观察了三硝基甲苯（TNT）10、50和100mg／kg剂量及4-氨基-2，6-二硝基甲苯（4-A）50、100和200mg/kg剂量对615小鼠睾丸初级精母细胞染色体畸变率的影响。实验结果显示，TNT和4－A诱发小鼠睾丸初级精母细胞染色体畸变率明显增高，呈剂量效应关系。表明它们都是性细胞染色体的诱变物，而且4－A的诱变活性与TNT相近。
The effects of trinitrotoluene (TNT) at doses of 10, 50 and 100 mg / kg and doses of 50, 100 and 200 mg / kg of 4-amino-2,6-dinitrotoluene (4-A) Influence of chromosome aberration rate of spermatocytes. The experimental results showed that the chromosome aberration rate of primary spermatocyte of mice induced by TNT and 4-A was significantly increased, showing a dose-response relationship. Indicating that they are all mutants of sex chromosomes, and the mutagenic activity of 4-A is similar to that of TNT.