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目的：探讨乳腺癌患者血清过氧化物酶（Peroxidase.POD）和肿瘤坏死因子（TumorNecrosisFactor.TNF）测定的临床意义。方法：测定30例乳腺癌，30例良性乳腺疾病和30例正常女性的血清POD活性和TNF含量，并对两者之间的关系。它们与肿瘤组织坏死程度及癌周淋巴细胞量的关系进行了分析。结果：乳腺癌患者血清POD活性明显升高，且与血清TNF含量密切相关。血清POD活性及TNF含量均与肿瘤坏死程度、癌周淋巴细胞量呈正相关。结论：血清POD可刺激巨噬细胞释放TNF等细胞介质，导致肿瘤坏死和癌周淋巴细胞侵润，测定血清POD活性可反映乳腺癌患者的免疫状态。血清POD活性的测定，还有助于乳腺癌的诊断及鉴别诊断。
Objective: To investigate the clinical significance of the determination of serum peroxidase (POD) and Tumor Necrosis Factor (TNF) in patients with breast cancer. Methods: The serum POD activity and TNF content in 30 cases of breast cancer, 30 cases of benign breast disease and 30 cases of normal women were determined, and the relationship between the two was discussed. Their relationship with the degree of tumor tissue necrosis and the amount of lymphocytes around the cancer was analyzed. RESULTS: Serum POD activity was significantly increased in breast cancer patients and was closely related to serum TNF levels. Serum POD activity and TNF content were positively correlated with the degree of tumor necrosis and the amount of lymphocytes around the cancer. Conclusion: Serum POD can stimulate macrophages to release TNF and other cell mediators, leading to tumor necrosis and invasion of pericancerous lymphocytes. Determination of serum POD activity can reflect the immune status of breast cancer patients. The determination of serum POD activity also contributes to the diagnosis and differential diagnosis of breast cancer.