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1962年Frantz等即发现猪的下丘脑含有刺激生长激素(GH)分泌的物质存在,1964年Deuben等用纯化的或部份纯化的下丘脑浸出液加入鼠垂体培养液中发现GH含量明显增加。1971年Schally等从猪下丘脑浸出液及垂体门脉血中分离出一种10肽,用生物鉴定法证实它可刺激GH分泌。1982年以来Guillemin,Rivier及Thorner等先后报告胰岛细胞肿瘤及类癌患者有典型肢端肥大症临床表现伴血中GH明显升高而
In 1962, Frantz et al. Found that the hypothalamus of pigs contain a substance that stimulates the secretion of growth hormone (GH). In 1964, Deuben et al. Found that the content of GH was significantly increased by adding purified or partially purified hypothalamic leachate into mouse pituitary culture. In 1971, Schally et al. Isolated a 10-peptide from the hypothalamus leech and pituitary portal blood and confirmed it by bioassay to stimulate GH secretion. Since 1982, Guillemin, Rivier and Thorner, etc. have reported that patients with islet cell carcinoma and carcinoid typical clinical manifestations of acromegaly with significant increase in blood GH