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目的 ①探讨子痫前期孕妇血清和胎盘组织中β-人绒毛膜促性腺激素(β-HCG)和抑制素-A(INH-A)的水平变化;②探讨子痫前期孕妇血清和胎盘组织中β-HCG和INH-A水平异常与子痫前期发病的相关性;③探讨子痫前期孕妇血清β-HCG和INH-A水平与子痫前期病情程度的相关性.方法 采集30例子痫前期患者及30例正常妊娠妇女外周血血清,用ELISA方法测其中INH-A、β-HCG水平变化.结果 ①子痫前期组INH-A、β-HCG水平均高于正常孕妇组(P<0.05),INH-A、β-HCG水平二者间成正相关(P<0.05).②子痫前期中INH-A、β-HCG与MAP、尿蛋白24 h定量均成正相关(P<0.05).结论 子痫前期孕妇胎盘组织中β-HCG、INH-A水平异常,可能通过影响滋养细胞的增殖、分化、浸润功能,从而影响胎盘血管床的发育,参与子痫前期的发病.②子痫前期孕妇血清中β-HCG、INH-A水平异常与血管内皮细胞受损有关,并且血清中β-HCG、INH-A水平与子痫前期的病情程度相关.③子痫前期孕妇血清中β-HCG与INH-A水平间呈正相关,二者也许在子痫前期的发病中具有相互作用,联合测定血清中β-HCG、INH-A水平将有助于子痫前期的辅助诊断和病情监测.“,”Objective ①To evaluate the changes of the levels of β-HCG and INH-A in the serum and placenta of the patients with preeclampsia.②To evaluate the correlation between the abnormality of the levels of β-HCG and INH-A in the serum and placenta and the morbidity of preeclampsia.③To evaluate the correlation between the levels of β-HCG and INH-A in the serum and the degree of severity of preeclampsia.Methods The serum levels of β-HCG and INH-A of patients with preeclampsia (study group) and 30 normal pregnantwomen (control group) were detected by ELISA.Results As compared with the control group,the serum levels of β-HCG and INH-Aof the patients in the study group elevated,and there is a significant difference between the control group and the study group (P<0.05).In the study group,the serum β-HCG levels correlated positively with the serum INH-Alevels(r=0.738,P<0.05 ).At the same time,the serum INH-A and β-HCG levels correlated positively with the blood urea nitrogen,the serum creatinine,the 24-hours proteinuria concentrations,and the diastolic blood pressure.