,Observation of the Ultrastructure in Syphilitic Chancres

• 作 者: ZHANG Xiaodong(张晓东) ZHOU Jing(周晶) WANG Dequan(王德权) WU Haiyan(吴海燕) SONG Fangji(宋芳吉)
• 机 构: Department of Dermatology,No.202 Hospital of P.L.A.,China“,”Department of Dermatology,No.1 Hospital
• 出 处: 中华性传播感染杂志（英文版）
• 发表日期: 2002年1期
• 关键词: Syphilitic chancre Treponema pallidum microscopy ultrastructure transmission ele

Objective:To study the occurrence and development of primary syphilis from a morphological and structural aspect.Method: The ultrastructural pathological changes of syphilitic chancre were examined by transmission electron microscopy (TEM).Results: The pathological changes of syphilitic chancre occur mainly in the dermal layer, manifested as partial thinning or lysis of the capillary basal membrane,proliferation of capillary endothelial cells, thickening of some collagen fibers and rupture of collagen fibers surrounding T.pallidum, structural disruption of the axous of terminal nerves,disarrangement of the sheath of the myelinated nerve fibers with separation of laminae and the attachment of T. Pallidum on its outer membrane, appearance of slightly swollen T.pallidum in the plasma of the capillary endothelial cells and fibroblasts, and infiltration of neutrophils, macrophages and plasma cells containing T. Pallidum and its debris frequently lined by a clear sheath.Conclusion: The pathogenesis and injury of mechanism in primary syphilis can be explained morphologically by its characteristic ultrastructural pathological changes.