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目的研究替硝唑联合中成药苦参凝胶调节微生态环境对治疗细菌性阴道病(bacterial vaginosis,BV)的临床意义。方法选取2013年11月至2015年5月我院符合BV诊断的女性患者102例,采用随机、剂量组平行对照临床试验,分为替硝唑组(对照组)、联合应用替硝唑及苦参凝胶组(治疗组),在停药的第1周、4周及8周分别随访患者1次,采用Amsel标准进行BV诊断及疗效评价。结果两组患者入组及第1次随访时各项指标无显著性差异,但是在第2次随访中显示对照组的疗效欠佳,且停药8周后对照组的复发率明显高于治疗组。结论苦参凝胶可以改善阴道微生态环境,治疗BV有效率高于对照组,且复发率低,安全有效。
Objective To study the clinical significance of tinidazole combined with Chinese medicine kushengel in the treatment of bacterial vaginosis (BV). Methods A total of 102 female patients with BV diagnosed in our hospital from November 2013 to May 2015 were randomly divided into tinidazole group (control group), clinical application of tinidazole and bitter tinidazole Ginseng gel group (treatment group) were followed up for 1 week, 4 weeks and 8 weeks respectively. The Amsel criteria were used to diagnose and evaluate the effects of BV. Results There was no significant difference between the two groups in the index and the first follow-up, but the second follow-up showed that the control group had poor efficacy and the recurrence rate of the control group was significantly higher than that of the control group after 8 weeks group. Conclusion Kushen gel can improve vaginal microenvironment, treatment of BV higher than the control group, and the recurrence rate is low, safe and effective.