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目的探讨脑心通联合美托洛尔治疗冠心病合并频发性室性期前收缩的临床疗效。方法选取黄冈市黄州区人民医院2014年9月—2016年9月收治的冠心病并频发性室性期前收缩患者122例,随机将患者分为对照组与研究组,各61例。对照组患者予以酒石酸美托洛尔治疗,观察组患者在对照组基础上联合脑心通胶囊治疗,两组患者均以4周为1个疗程,连续治疗2个疗程。比较两组患者临床疗效、心功能指标[左心室射血分数(LVEF)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)]、24 h期前收缩次数、治疗满意率及不良反应发生情况。结果研究组患者总有效率高于对照组(P<0.05)。治疗前两组患者LVEF、LVESD、LVEDD、24h期前收缩次数比较,差异无统计学意义(P>0.05);治疗后研究组患者LVEF高于对照组,24 h期前收缩次数少于对照组(P<0.05);治疗后两组患者LVESD、LVEDD比较,差异无统计学意义(P>0.05)。研究组患者治疗满意率高于对照组(P<0.05)。两组患者均无严重不良反应发生。结论脑心通联合美托洛尔治疗冠心病合并频发性室性期前收缩的临床疗效确切,可有效改善患者心功能,提高治疗满意度,且安全性高。
Objective To investigate the clinical efficacy of Naoxintong combined with metoprolol in the treatment of coronary heart disease complicated with frequent ventricular premature contractions. Methods A total of 122 patients with coronary heart disease and frequent ventricular premature contractions admitted to the Huangzhou People’s Hospital of Huanggang District from September 2014 to September 2016 were randomly divided into control group and study group, with 61 cases in each group. Patients in the control group were treated with metoprolol tartrate. The patients in the observation group were treated with Naoxintong capsule on the basis of the control group. Both groups were given 1 course of treatment for 4 weeks and were treated for 2 courses continuously. The clinical efficacy, cardiac function index (LVEF, LVESD, LVEDD), the number of contraction before 24 h, the satisfaction rate of treatment and Adverse reactions occurred. Results The total effective rate of study group was higher than that of control group (P <0.05). Before treatment, LVEF, LVESD, LVEDD and the number of contractions before 24h had no statistical significance (P> 0.05). After treatment, the LVEF in study group was higher than that in control group, and the number of contractions before 24 h was less than that in control group (P <0.05). There was no significant difference in LVESD and LVEDD between the two groups after treatment (P> 0.05). The satisfaction rate of patients in study group was higher than that in control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Naoxintong combined with metoprolol in the treatment of coronary heart disease complicated with frequent premature ventricular contractions clinical curative effect can effectively improve the patient’s cardiac function, improve the satisfaction of treatment, and high safety.