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目的:检测女性压力性尿失禁患者阴道壁组织中Fibulin-3、TIMP-3和elastin的表达,探讨其与压力性尿失禁(SUI)的关系。方法:选取30例女性SUI患者作为研究组(SUI组),选择同期30例盆底器官脱垂患者(POP组)、30例妇科良性疾病患者作为对照组,采用免疫组织化学法(SP二步法)检测阴道壁组织中Fibulin-3、TIMP-3和elastin的表达。结果:Fibulin-3、TIMP-3和elastin在SUI组和POP组患者中的表达明显低于对照组,差异有统计学意义(P<0.05)。Fibulin-3、TIMP-3和elastin在SUI组和POP组患者中的表达差异无统计学意义(P>0.05)。SUI组Fibulin-3与TIMP-3的表达呈正相关,Fibulin-3和elastin的表达无明显的相关性。结论:Fibulin-3表达降低,TIMP-3活性降低,盆底支持组织胶原和elastin降解增加,组织弹性降低,盆底结构松弛,可能与压力性尿失禁的发生有关。
Objective: To investigate the expression of Fibulin-3, TIMP-3 and elastin in vaginal wall tissues of female stress urinary incontinence patients and to explore the relationship between them and stress urinary incontinence (SUI). Methods: Thirty female SUI patients were selected as study group (SUI group) .30 cases of pelvic floor organ prolapse (POP group) and 30 cases of benign gynecological diseases were selected as control group. Immunohistochemistry Method) to detect the expression of Fibulin-3, TIMP-3 and elastin in vaginal wall tissue. Results: The expressions of Fibulin-3, TIMP-3 and elastin in SUI group and POP group were significantly lower than those in control group (P <0.05). The expression of Fibulin-3, TIMP-3 and elastin in SUI group and POP group had no significant difference (P> 0.05). There was a positive correlation between the expression of Fibulin-3 and TIMP-3 in SUI group, but there was no significant correlation between the expression of Fibulin-3 and elastin. CONCLUSION: The decrease of Fibulin-3, the decrease of TIMP-3 activity, the increase of collagen and elastin in pelvic floor support tissues, the decrease of elasticity and relaxation of pelvic floor may be related to the occurrence of stress urinary incontinence.