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应用ELISA双抗体夹心法对HSP患儿血清TNF-α、IL-6、IL-8活性水平进行测定。结果表明。患儿血清TNF-α、IL-6、IL-8活性水平均较正常对照显著升高(P<0.01),尤以伴肾脏损害者为著。提示TNF-α、IL-6、IL-8参与HSP的发生发展。本研究有助于进一步阐明HSP的发病机制。
Serum levels of TNF-α, IL-6 and IL-8 in children with HSP were measured by ELISA double antibody sandwich method. The results show. Serum levels of TNF-α, IL-6 and IL-8 in children were significantly higher than those in normal controls (P <0.01), especially those with kidney damage. Tip TNF-α, IL-6, IL-8 involved in the occurrence and development of HSP. This study will help further elucidate the pathogenesis of HSP.