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将紫外线灭活的疱疹病毒Ⅱ型(HSV-2),小剂量的小鼠白血病病毒(MuLV)、HSV-2加MuLV分别接种三个实验组的成年小鼠,对照组小鼠不接种任何病毒。结果在四个组中仅HSV-2加MuLV组和MuLV组的动物发生了淋巴细胞白血病,其发病率分别为12.96％(7/54)和1.92％(1/52),二者之间差异有显著性(P<0.05);而且前者的白血病发病时间较后者要早。提示HSV-2与MuLV在诱发小鼠淋巴细胞白血病过程中具有协同作用,其中的HSV-2只是一种“促癌因素”。
UV-inactivated herpes virus type 2 (HSV-2), low-dose mouse leukemia virus (MuLV), HSV-2 plus MuLV were inoculated with three experimental groups of adult mice, respectively. The control mice were not vaccinated with any virus. . Results Lymphocytic leukemia occurred in animals of the HSV-2 plus MuLV group and MuLV group in four groups. The incidence rates were 12.96% (7/54) and 1.92% (1/52), respectively. Significant (P < 0.05); and the former leukemia earlier than the latter. It suggests that HSV-2 and MuLV have a synergistic effect in inducing lymphocytic leukemia in mice, and that HSV-2 is only a “promoting factor”.