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羰基化合物的氟烷基化反应是把含氟基团引入有机分子中去的一个重要手段。文献报道的主要是通过氟烷基金属试剂来进行此反应。但氟烷基金属试剂不太稳定,容易分解。这就给它们的应用带来了许多不便。我们发现,氟烷基三甲基硅化合物(1)作为氟烷基阴离子前体,在比较温和的条件下,便可使醛发生氟烷基化反应。首先,参照文献方法,通过氟烷基格氏试剂与三甲基氯硅烷反应,方便地制得了两个新的氟烷基三甲基硅化合物 R_F-SiMe_3(1)。
Fluoroalkylation of carbonyl compounds is an important means of introducing fluorine-containing groups into organic molecules. Reported in the literature mainly through fluoroalkyl metal reagents to carry out this reaction. But fluoroalkyl metal reagent is not stable, easy to decompose. This has brought a lot of inconvenience to their application. We have found that fluoroalkyl trimethylsilyl compounds (1), as fluoroalkyl anion precursors, give fluoroalkylation of aldehydes under milder conditions. First of all, two new fluoroalkyl trimethylsilyl compounds R_F-SiMe_3 (1) were prepared by the reaction of fluoroalkyl Grignard reagent with trimethylchlorosilane according to the literature method.